Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application
| Autor: | Ryuji Toh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Clinical settings
High-density lipoprotein (HDL) Review 030204 cardiovascular system & hematology Pharmacology Risk Assessment 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal Medicine Cholesterol uptake Medicine Animals Humans In patient Cholesterol efflux capacity (CEC) Lipoprotein cholesterol Cholesterol business.industry Biochemistry (medical) Cholesterol HDL Cardiovascular disease Cholesterol uptake capacity (CUC) Prognosis HDL cholesterol (HDL-C) chemistry Cardiovascular Diseases Risk stratification cardiovascular system lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | While there is a controversy regarding the causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with the incidence of CVD. However, there are several limitations to current assays of CEC. First, CEC measurements are not instantly applicable in clinical settings, because CEC assay methods require radiolabeled cholesterol and cultured cells, and these procedures are time consuming. Second, techniques to measure CEC are not standardized. Third, the condition of endogenous cholesterol donors would not be accounted for in the CEC assays. Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)". We demonstrated that CUC represents a residual cardiovascular risk in patients with optimal low-density lipoprotein cholesterol control independently of traditional risk factors, including HDL-C. Establishing reproducible approaches for the cholesterol removal capacity of HDL is required to validate the impact of dysfunctional HDL on cardiovascular risk stratification in the "real world". |
| Databáze: | OpenAIRE |
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