Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)

Autor: Karolina Dukik, Christina A. Cuomo, Lynne Sigler, Bert Gerrits van den Ende, Joanna Freeke, Oliver K. Clay, Ilan S. Schwartz, Juan G. McEwen, Andrew M. Borman, Chris Kenyon, J. Benjamin Stielow, Sybren de Hoog, Yanping Jiang, Peiying Feng, Nelesh P. Govender, Leandro F. Moreno, José F. Muñoz, Azadeh Jamalian, Tsidiso G. Maphanga
Přispěvatelé: Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Medical Mycology
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Blastomyces gilchristii
Spores
Unclassified drug
Genomic DNA
Ajellomycetaceae
Paracoccidioides
Chrysosporium
South Africa
Sequence alignment
Genus
Molecular genetics
Emmonsia pasteuriana
DNA extraction
Emergomyces orientalis
Phylogeny
Cell budding
Priority journal
Fungal protein
Microscopy
Genome
biology
60S ribosomal protein
Blastomyces percursus
Phylogenomics
Emmonsia
Fungus spore
General Medicine
Onygenales
Genomics
Spores
Fungal
Classification
New species
Type species
Infectious Diseases
Phenotype
Fungal
Ultrastructure
Fungal genome
Blastomyces
Emergomyces pasteurianus
Genome
Fungal
Beta tubulin
Sequence Analysis
Human
Emergomyces africanus
030106 microbiology
Histoplasma
DNA sequence
Zoology
Dermatology
Microbiology
Article
03 medical and health sciences
Phylogenetics
Ajellomyces dermatitidis
Morphological trait
Emergomyces
Genetics
Pathogenicity
Humans
Biology
Mycelium
Fungal strain
Sequence Analysis
DNA
DNA
biology.organism_classification
Nonhuman
Fungal DNA
Mycoses
Whole genome sequencing
North America
Human medicine
Comparative study
Emmonsia parva
Controlled study
Nucleotide sequence
Emmonsia crescens
Elongation factor 3
Zdroj: Mycoses. John Wiley and Sons Ltd
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
Mycoses: diagnosis, therapy and prophylaxis of fungal diseases
ISSN: 0933-7407
Popis: Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus. © 2017 Blackwell Verlag GmbH
Databáze: OpenAIRE
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