Prognostication by inflammation-based score in patients with locally advanced pancreatic cancer treated with chemoradiotherapy

Autor: Sumiya Ishigami, Satoshi Iino, Kiyokazu Hiwatashi, Shoji Natsugoe, Hiroshi Kurahara, Hiroyuki Shinchi, Yuko Mataki, Sonshin Takao, Takaaki Arigami, Yuko Kijima, Yota Kawasaki, Masahiko Sakoda, Kosei Maemura
Rok vydání: 2015
Předmět:
Zdroj: Pancreatology. 15:688-693
ISSN: 1424-3903
DOI: 10.1016/j.pan.2015.09.015
Popis: An association between inflammatory/immunonutritional status and patient prognosis has been reported in various types of cancer. The aim of this study was to evaluate the utility of inflammatory/immunonutritional factors as therapeutic predictors for patients with locally advanced pancreatic cancer treated with chemoradiotherapy (CRT).Ninety-six patients with histologically proven locally advanced pancreatic adenocarcinoma who underwent CRT were enrolled in this study. We evaluated significance of inflammation-based factors as predictors of therapeutic effect and prognosis.The median progression free survival (PFS) and overall survival (OS) of all patients was 10 and 18 months, respectively. A Glasgow prognostic score (GPS) of 2 and plasma fibrinogen levels ≥ 400 mg/dL were independent predictors of poor PFS and OS. A prognostic nutritional index (PNI) ≥ 45 was a predictor of a significantly better reduction rate of the primary tumor. The prognosis between patients with GPS 0/1 and fibrinogen400 mg/dL, GPS 2 or fibrinogen ≥400 mg/dL, and GPS 2 and fibrinogen ≥400 mg/dL were significantly different. Patients with GPS 2 and/or plasma fibrinogen ≥ 400 mg/dL had significantly higher incidence of metastasis within 6 months after CRT.GPS, fibrinogen, PNI are useful therapeutic and prognostic predictors in patients with locally advanced pancreatic cancer treated with CRT.
Databáze: OpenAIRE
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