Aqueous Synthesis of Triphenylphosphine‐Modified Gold Nanoparticles for Synergistic In Vitro and In Vivo Photothermal Chemotherapy
| Autor: | Renu Pasricha, Kirsten C. Sadler, Thirumurugan Prakasam, Ali Trabolsi, Yaereen Dho, Anjana Ramdas Nair, Farah Benyettou, Javed Mazher, Hassan Traboulsi, Jamie Whelan |
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| Rok vydání: | 2020 |
| Předmět: |
Polymers
Metal Nanoparticles Nanoparticle Antineoplastic Agents 010402 general chemistry 01 natural sciences Catalysis HeLa chemistry.chemical_compound Organophosphorus Compounds Humans Triphenylphosphine Photodegradation Aqueous solution biology 010405 organic chemistry Organic Chemistry Temperature General Chemistry Phototherapy Photothermal therapy Poloxamer biology.organism_classification 0104 chemical sciences chemistry Colloidal gold Gold HeLa Cells Nuclear chemistry |
| Zdroj: | Chemistry – A European Journal. 26:5270-5279 |
| ISSN: | 1521-3765 0947-6539 |
| Popis: | Triphenylphosphine (TPP) surface-functionalized and F-108 Pluronic-stabilized gold nanoparticles (F-108@TPP-AuNPs) have been synthesized through a one-step approach, leading to well-defined (9.6±1.6 nm) and water-soluble nanoparticles by microwave heating an aqueous solution of TPP-AuI Cl in the presence of a Pluronic polymer under basic conditions. TPP release was negligible under physiological conditions, but enhanced significantly at an acidic pH (5.4) mimicking that of a cancer cell. Laser irradiation (532 nm) raised the temperature of an aqueous solution of F-108@TPP-AuNPs to 51.7 °C within 5 min, confirming efficient light-to-heat conversion capabilities without significant photodegradation. TEM confirmed intracellular localization of F-108@TPP-AuNPs in the cytosol, endosomes and lysosomes of HeLa cells. F-108@TPP-AuNPs were well tolerated by HeLa cells and zebrafish embryos at ambient temperatures and became toxic upon heat activation, suggesting synergistic interactions between heat and cytotoxic action by TPP. |
| Databáze: | OpenAIRE |
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