Chemical constituents from Bauhinia acuruana and their cytotoxicity
| Autor: | Horlando C. da Silva, Paulo B.N. da Silva, Francisco J.T. Gonçalves, Angela M. C. Arriaga, Francisco Erivaldo Freitas da Silva, Gilvandete M. P. Santiago, Telma L. G. Lemos, Leôncio Mesquita de Sousa, Gardenia C.G. Militão, Mary Anne Sousa Lima, Roberto Wagner da Silva Góis, Raimundo Braz-Filho, Antônia Torres Ávila Pimenta |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Flavonoids
biology Traditional medicine 010405 organic chemistry Bauhinia Stereochemistry Chemical structure Terpenoids Cytotoxicity lcsh:RS1-441 Fabaceae biology.organism_classification 01 natural sciences Terpenoid 0104 chemical sciences Oxepin derivatives lcsh:Pharmacy and materia medica 010404 medicinal & biomolecular chemistry Phytochemical Bibenzyls General Pharmacology Toxicology and Pharmaceutics Medicinal plants Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Revista Brasileira de Farmacognosia v.27 n.6 2017 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 27, Iss 6, Pp 711-715 (2017) Revista Brasileira de Farmacognosia, Volume: 27, Issue: 6, Pages: 711-715, Published: DEC 2017 Revista Brasileira de Farmacognosia, Vol 27, Iss 6, Pp 711-715 |
| Popis: | Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2′-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4′-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3–16). The structures of the compounds were established by spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human cancer cell lines. Keywords: Fabaceae, Bibenzyls, Oxepin derivatives, Flavonoids, Terpenoids, Cytotoxicity |
| Databáze: | OpenAIRE |
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