In vivo methods for the assessment of topical drug bioavailability
| Autor: | François-Xavier Mathy, Véronique Préat, Yogeshvar N. Kalia, Christophe Herkenne, Ingo Alberti, Richard H. Guy, Aarti Naik |
|---|---|
| Přispěvatelé: | UCL - MD/FARM - Ecole de pharmacie |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Drug
dermatopharmacokinetics Tape stripping microdialysis media_common.quotation_subject Administration Topical Microdialysis Skin Absorption Pharmaceutical Science Biological Availability Pharmacology Pharmacokinetics In vivo Medicine Humans Pharmacology (medical) cutaneous bioavailability Dermatopharmacokinetics media_common Skin ddc:615 Topical drug Microscopy Confocal business.industry tape stripping Organic Chemistry Topical drug application Suction blister Bioavailability cutaneous drug concentration Pharmaceutical Preparations Cutaneous bioavailability Cutaneous drug concentration Molecular Medicine business Expert Review Confocal raman spectroscopy Algorithms Biotechnology Biomedical engineering |
| Zdroj: | Pharmaceutical Research, Vol. 25, no. 1, p. 87-103 (2008) Herkenne, C, Alberti, I, Naik, A, Kalia, Y N, Mathy, F X, Préat, V & Guy, R H 2008, ' In vivo methods for the assessment of topical drug bioavailability ', Pharmaceutical Research, vol. 25, no. 1, pp. 87-103 . https://doi.org/10.1007/s11095-007-9429-7 Pharmaceutical Research Pharmaceutical Research, Vol. 25, No 1 (2008) pp. 87-103 |
| ISSN: | 0724-8741 |
| DOI: | 10.1007/s11095-007-9429-7 |
| Popis: | This paper reviews some current methods for the in vivo assessment of local cutaneous bioavailability in humans after topical drug application. After an introduction discussing the importance of local drug bioavailability assessment and the limitations of the predictive calculations, the focus turns to the relevance of experimental studies. The available techniques are then reviewed in detail, with particular emphasis on the tape stripping and microdialysis methodologies. Other less developed techniques, including the skin biopsy, suction blister, follicle removal and confocal Raman spectroscopy techniques are also described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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