SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells: Focus on Microsatellite Stability
| Autor: | Seon Ae Roh, Jin Cheon Kim, Yi Hong Kwon, Jong Lyul Lee, Seon-Kyu Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cytotoxicity
Immunologic Cancer Research THP-1 Cells Colorectal cancer medicine.medical_treatment Programmed Cell Death 1 Receptor Apoptosis Biology Immune system Cell Movement Signaling Lymphocytic Activation Molecule Family Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Invasiveness HMGB1 Protein Immune Checkpoint Inhibitors neoplasms Cell Proliferation General Medicine Immunotherapy HCT116 Cells medicine.disease Coculture Techniques Triggering Receptor Expressed on Myeloid Cells-1 digestive system diseases Gene Expression Regulation Neoplastic Cytokine Oncology Cell culture Cancer research Immunogenic cell death Microsatellite Instability Colorectal Neoplasms HT29 Cells Adjuvant Signal Transduction |
| Zdroj: | Anticancer Research. 41:5431-5444 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.15355 |
| Popis: | BACKGROUND/AIM The aim of this study was to identify the association between SLAMF7 and TREM1 and anti-PD-1 drugs, and to determine whether they are molecular targets or predictors of responses to immunotherapy through induction of immunogenic cell death. MATERIALS AND METHODS CRC cell lines over-expressing SLAMF7 and TREM1 were used to examine immunogenic and biological traits (e.g., proliferation and invasiveness) associated with factors related to anti-cancer immunity. In addition, multiplex immunofluorescence was used to examine immune cells in microsatellite instability-high (MSI-H) CRC and microsatellite stable (MSS) CRC. RESULTS Proliferation rate and invasiveness of TREM1-over-expressing CRC cells were significantly greater than those of control cells (p |
| Databáze: | OpenAIRE |
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