Dietary arachidonic and linoleic acids: Comparative effects on tissue lipids
| Autor: | Jay Whelan, Marc E. Surette, John E. Kinsella, K. S. Broughton |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Ratón Clinical chemistry Linoleic acid Phospholipid Biology Biochemistry Linoleic Acid Mice chemistry.chemical_compound Dietary Fats Unsaturated Internal medicine Phosphatidylcholine medicine Animals Peritoneal Lavage Peritoneal Cavity Phospholipids chemistry.chemical_classification Arachidonic Acid Macrophages Fatty Acids Organic Chemistry Cell Biology Endocrinology Linoleic Acids Liver chemistry Arachidonic acid Polyunsaturated fatty acid Lipidology |
| Zdroj: | Lipids. 27:85-88 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/bf02537068 |
| Popis: | The effects of preformed dietary arachidonic acid (AA, 20:4n-6) on murine phospholipid fatty acid composition in tissues capable (liver) and incapable (peritoneal exudate cells, PEC) of desaturating and elongating linoleic acid (LA, 18:2n-6) to AA were investigated. The results were compared with those obtained on matched animals on LA diets by either substituting or supplementing dietary LA with AA. Modest amounts of AA ethyl ester (0.5 wt%) included in the diet significantly increased tissue phospholipid AA levels by 39% and 57% in the liver and in PEC, respectively. The changes were further enhanced when dietary LA and AA intakes were equivalent, i.e., 57% and 68% in liver and PEC, respectively. This enrichment was observed in all phospholipid classes analyzed, with the greatest impact on phosphatidylcholine. In addition, the doubling of dietary LA had little effect on tissue phospholipid AA levels. The data suggest that while the level of n-6 PUFA may have an important effect on tissue fatty acid composition, the type of n-6 PUFA in the diet could be of greater significance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink