Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-κB inhibitor
| Autor: | Makoto Sawada, Hiroshi Takatsuna, S. Morita, Toshiharu Nagatsu, Kazuo Umezawa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Lipopolysaccharide medicine.medical_treatment Inflammation Biology Cell Line Mice chemistry.chemical_compound Internal medicine medicine Animals Electrophoretic mobility shift assay Pharmacology Dose-Response Relationship Drug Microglia Cyclohexanones Interleukin-6 Tumor Necrosis Factor-alpha NF-kappa B NF-κB General Medicine Cytokine Endocrinology medicine.anatomical_structure chemistry Benzamides Cancer research Cytokines Neuroglia Cytokine secretion medicine.symptom |
| Zdroj: | Biomedicine & Pharmacotherapy. 59:318-322 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2005.01.011 |
| Popis: | Activation of microglia has been implicated in various neurodegenerative disorders, and thus the inhibition of microglial activity may suppress these disorders. Earlier we designed and synthesized an NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) that showed anti-inflammatory and anti-tumor activities in vivo. In the present research, we studied whether DHMEQ would inhibit the activation of mouse microglial cells. DHMEQ inhibited lipopolysaccharide (LPS)-induced activation of NF-kappaB in an electrophoresis mobility shift assay. It also inhibited LPS-induced secretions of TNF-alpha and IL-6 from mouse microglial cell line 6-1 cells. |
| Databáze: | OpenAIRE |
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