'Differential risk of hospitalization among single virus infections causing influenza‐like illnesses'
| Autor: | Ana A Ortiz-Hernández, Maria de Lourdes Guerrero, Rafael Valdez Vázquez, Alejandra Ramírez-Venegas, Ana Esthela Gamiño, Daniel E. Noyola, Martín Magaña Aquino, Diana Andrade-Platas, John H. Beigel, Sally Hunsberger, Beatriz Llamosas-Gallardo, Sarbelio Moreno-Espinosa, Raydel Valdés Salgado, Arturo Galindo-Fraga, Juliana Estevez-Jimenéz, Guillermo M. Ruiz-Palacios, Katherine K. Nishimura, Laura Freimanis-Hence, Mary Smolskis |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Epidemiology viruses single virus Respiratory Syncytial Virus Infections 030312 virology medicine.disease_cause Lower risk Severity of Illness Index Virus 03 medical and health sciences Influenza Human Odds Ratio Medicine Humans Metapneumovirus Prospective Studies Mexico Respiratory Tract Infections Coronavirus 0303 health sciences Influenza-like illness influenza‐like illness Paramyxoviridae Infections business.industry Public Health Environmental and Occupational Health virus diseases Infant Odds ratio Original Articles respiratory system Virology respiratory tract diseases Hospitalization Infectious Diseases Virus Diseases Child Preschool acute respiratory infection Acute Disease Viruses Enterovirus Original Article Female Rhinovirus business |
| Zdroj: | Influenza and Other Respiratory Viruses |
| ISSN: | 1750-2659 1750-2640 |
| Popis: | BACKGROUND Acute respiratory infections are a major cause of morbidity in children and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza-like illness (ILI). METHODS Data from children 5 years old or younger participating in an ILI natural history study from April 2010 to March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (RSV), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus/enterovirus, coronavirus, adenovirus, and influenza. RESULTS A total of 1486 children (408 outpatients and 1078 inpatients) were included in this analysis. At least one virus was detected in 1227 (82.6%) patients. The most frequent viruses detected as single pathogens were RSV (n = 286), rhinovirus/enterovirus (n = 251), parainfluenza viruses (n = 104), and influenza A or B (n = 99). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment, and underlying illnesses), children with RSV and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (OR 2.7 and 1.9, respectively), rhinovirus/enterovirus (OR 3.1 and 2.1, respectively), coronaviruses (OR 4.9 and 3.4, respectively), adenovirus (OR 4.6 and 3.2, respectively), and influenza (OR 6.3 and 4.4, respectively). CONCLUSIONS Children presenting with ILI caused by RSV and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization. |
| Databáze: | OpenAIRE |
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