Genetic polymorphism in pathogenesis of irritable bowel syndrome
| Autor: | Cynthia K. Cheung, Justin C.Y. Wu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetic Markers
medicine.medical_specialty Gastroenterology Irritable Bowel Syndrome Pathogenesis Functional gastrointestinal disorder Risk Factors Polymorphism (computer science) Internal medicine Humans Medicine Genetic Predisposition to Disease Topic Highlight Defecation Irritable bowel syndrome Polymorphism Genetic business.industry Neuropeptides General Medicine Prognosis Rome iii medicine.disease Pathophysiology Phenotype Genetic marker Cytokines business |
| Zdroj: | World Journal of Gastroenterology. 20:17693-17698 |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v20.i47.17693 |
| Popis: | Irritable bowel syndrome (IBS) is a complex symptom-based disorder without established biomarkers or putative pathophysiology. IBS is a common functional gastrointestinal disorder which is defined as recurrent abdominal pain or discomfort that has at least two of the following symptoms for 3 d per month in the past 3 mo according to ROME III: relief by defecation, onset associated with a change in stool frequency or onset with change in appearance or form of stool. Recent discoveries revealed genetic polymorphisms in specific cytokines and neuropeptides may possibly influence the frequencies and severity of symptoms, as well as the therapeutic responses in treating IBS patients. This review gives new insights on how genetic determinations influence in clinical manifestations, treatment responses and potential biomarkers of IBS. |
| Databáze: | OpenAIRE |
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