Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
| Autor: | Ellen Tuck, Laurence Dion-Albert, Caroline Menard, Katarzyna Anna Dudek, Fernanda Neutzling Kaufmann, Manon Lebel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
sex differences
Male media_common.quotation_subject blood–brain barrier Affect (psychology) stress Mice 03 medical and health sciences 0302 clinical medicine vascular Neurobiology Adaptation Psychological medicine Animals Humans Chronic stress Social isolation Depression (differential diagnoses) Special Issue: Depression 030304 developmental biology media_common Depressive Disorder Major 0303 health sciences Depression business.industry General Neuroscience Anhedonia medicine.disease Special Issue Review cytokines Antidepressive Agents Major depressive disorder Antidepressant Female Psychological resilience immune medicine.symptom business Stress Psychological 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | The European Journal of Neuroscience |
| ISSN: | 1460-9568 0953-816X |
| DOI: | 10.1111/ejn.14547 |
| Popis: | Major depressive disorder (MDD) is a chronic and recurrent psychiatric condition characterized by depressed mood, social isolation and anhedonia. It will affect 20% of individuals with considerable economic impacts. Unfortunately, 30–50% of depressed individuals are resistant to current antidepressant treatments. MDD is twice as prevalent in women and associated symptoms are different. Depression's main environmental risk factor is chronic stress, and women report higher levels of stress in daily life. However, not every stressed individual becomes depressed, highlighting the need to identify biological determinants of stress vulnerability but also resilience. Based on a reverse translational approach, rodent models of depression were developed to study the mechanisms underlying susceptibility vs resilience. Indeed, a subpopulation of animals can display coping mechanisms and a set of biological alterations leading to stress resilience. The aetiology of MDD is multifactorial and involves several physiological systems. Exacerbation of endocrine and immune responses from both innate and adaptive systems are observed in depressed individuals and mice exhibiting depression‐like behaviours. Increasing attention has been given to neurovascular health since higher prevalence of cardiovascular diseases is found in MDD patients and inflammatory conditions are associated with depression, treatment resistance and relapse. Here, we provide an overview of endocrine, immune and vascular changes associated with stress vulnerability vs. resilience in rodents and when available, in humans. Lack of treatment efficacy suggests that neuron‐centric treatments do not address important causal biological factors and better understanding of stress‐induced adaptations, including sex differences, could contribute to develop novel therapeutic strategies including personalized medicine approaches. Endocrine, immune and vascular aspects contributing to depression and resilience. Evidence from mouse and human studies highlighted sex‐specific roles of these three different, but associated, systems in major depressive disorder and resilience. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text