A novel method of esophageal lengthening in a large animal model of long gap esophageal atresia
| Autor: | Steven L. Lee, James C.Y. Dunn, Samuel W. French, Benjamin M. Wu, Veronica F. Sullins, Peter K. Traum |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Muscularis mucosae Swine Gastroesophageal Junction Esophagus medicine Animals Esophageal Atresia Esophageal segment business.industry Anastomosis Surgical Esophageal lengthening General Medicine Long gap esophageal atresia Esophageal pouch Surgery medicine.anatomical_structure Esophagoplasty Pediatrics Perinatology and Child Health Swine Miniature Esophagogastric Junction Stress Mechanical business Large animal |
| Zdroj: | Journal of Pediatric Surgery. 50:928-932 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2015.03.011 |
| Popis: | Purpose Long gap esophageal atresia remains a significant treatment challenge. We aimed to create the first large animal model of long gap esophageal atresia to test a degradable esophageal lengthening device. Methods The distal esophagus was divided 2 cm above the gastroesophageal junction in 6 minipigs. A polycaprolactone (PCL) spring device was secured inside the distal esophageal segment, and the end was oversewn. Nonexpanding PCL tubes served as controls. An esophagogastric anastomosis was created to restore continuity. After 4 weeks, the distal esophageal pouch was analyzed. Results The distal esophageal pouch of experimental animals increased in length from 1.9 to 4.5 cm. Control animals demonstrated no change. When comparing lengthened to native esophagus, there was no difference in the thickness of muscularis mucosa or muscularis propria. Mechanically lengthened esophagus showed mild to moderate superficial inflammation and fibrosis. There were no differences in the number of myenteric or submucosal ganglia. Conclusion We created the first porcine model of long gap esophageal atresia and lengthened the distal esophagus with an internally placed device. This model may be used to explore novel therapies in the management of long gap esophageal atresia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect