Adiponectin and peroxisome proliferator-activated receptor-γ gene polymorphisms and gene-gene interactions with type 2 diabetes
| Autor: | Mengmeng Peng, Xuemian Lu, Qing-Shou Chen, Hong Yang, Enling Ye, Mengli Sun, Liangmiao Chen, Zhenzhen Lin, Chi Zhang, Lechu Yu |
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| Rok vydání: | 2014 |
| Předmět: |
Male
China medicine.medical_specialty Population Single-nucleotide polymorphism Biology Bioinformatics General Biochemistry Genetics and Molecular Biology Polymorphism (computer science) Internal medicine medicine Humans Genetic Predisposition to Disease General Pharmacology Toxicology and Pharmaceutics education education.field_of_study Polymorphism Genetic Multifactor dimensionality reduction Adiponectin Haplotype nutritional and metabolic diseases Epistasis Genetic General Medicine Middle Aged Genotype frequency PPAR gamma Endocrinology Diabetes Mellitus Type 2 Female Gene polymorphism |
| Zdroj: | Life Sciences. 98:55-59 |
| ISSN: | 0024-3205 |
| Popis: | Aims To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPARγ) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and whether the interaction of gene polymorphism between adiponectin and PPARγ influences T2DM in the same subjects. Main methods This study included 198 patients with T2DM and 255 healthy individuals. Polymerase chain reaction–restriction fragment length polymorphism analyses were used to detect single nucleotide polymorphisms (SNPs). Logistic regression and multifactor dimensionality reduction (MDR) methods were used to analyze gene–gene interactions. Key findings The frequency distribution of adiponectin SNP11377 was not different (p = 0.792), but the frequency of CC, CG and GG genotypes showed the difference between two groups (T2DM: 57.1%, 33.3%, and 9.6%; control: 53.7%, 41.6%, and 4.7%, respectively; p = 0.047). Adiponectin SNP45, SNP276 and PPAR γ SNPp12a were equally distributed between the two groups (p = 0.586, 0.119, 0.437, respectively), and there were no significant differences in genotype frequencies between the two groups (p = 0.751, 0.144, 0.479, respectively). Linkage disequilibrium existed between SNP11377 and SNP45 (p |
| Databáze: | OpenAIRE |
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