Rational Design of Constrained Peptides as Protein Interface Inhibitors
| Autor: | Lian Lam, Ramachandran Murali, Hongtao Zhang, Mark I. Greene, Zheng Cai |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Chemistry mimetic ErbB receptor Immunology Rational design TNF Peptide protein-engineering Protein engineering Computational biology Review RC581-607 Small molecule Structural biology Cell surface receptor Drug Discovery Immunology and Allergy cancer Immunologic diseases. Allergy Receptor immunoadhesion |
| Zdroj: | Antibodies Antibodies, Vol 10, Iss 32, p 32 (2021) |
| ISSN: | 2073-4468 |
| Popis: | The lack of progress in developing targeted therapeutics directed at protein–protein complexes has been due to the absence of well-defined ligand-binding pockets and the extensive intermolecular contacts at the protein–protein interface. Our laboratory has developed approaches to dissect protein–protein complexes focusing on the superfamilies of erbB and tumor necrosis factor (TNF) receptors by the combined use of structural biology and computational biology to facilitate small molecule development. We present a perspective on the development and application of peptide inhibitors as well as immunoadhesins to cell surface receptors performed in our laboratory. |
| Databáze: | OpenAIRE |
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