Insignificant Effect of Isolated Hypothyroxinemia on Pregnancy Outcomes During the First and Second Trimester of Pregnancy
| Autor: | Enling Ye, Zhenzhen Lin, Lechu Yu, Xuemian Lu, Hong Yang, Hai Lin, Mengmeng Peng, Zhuhua Cai, Liangmiao Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Gestational hypertension medicine.medical_specialty endocrine system Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Thyroid Function Tests lcsh:Diseases of the endocrine glands. Clinical endocrinology Young Adult 03 medical and health sciences Endocrinology 0302 clinical medicine Maternal hypothyroidism Hypothyroidism Pregnancy medicine Humans Euthyroid perinatal complication Original Research isolated hypothyroxinemia pregnancy outcome lcsh:RC648-665 Placental abruption Obstetrics business.industry Infant Newborn Infant Low Birth Weight medicine.disease maternal outcome Pregnancy Complications Gestational diabetes Pregnancy Trimester First Thyroxine Low birth weight 030104 developmental biology Hypothyroxinemia Pregnancy Trimester Second Female second trimester medicine.symptom business first trimester |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2020) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2020.528146 |
| Popis: | Objective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The aim of this study was to evaluate the effects of isolated hypothyroxinemia on maternal and perinatal outcomes during pregnancy. Methods: This study included data from 2,864 pregnant women in the first trimester (67 women with isolated hypothyroxinemia, 784 euthyroid women) and the second trimester (70 women with isolated hypothyroxinemia, 1,943 euthyroid women) of pregnancy. Maternal serum samples were collected in the first and second trimesters to examine thyroid hormone concentration. Hypothyroxinemia was defined as a normal maternal thyroid-stimulating hormone concentration with a low maternal free thyroxine concentration and negative thyroid autoantibodies. The following maternal outcomes were recorded: gestational hypertension, gestational diabetes mellitus, placenta previa, placental abruption, prelabor rupture of membranes, and premature delivery. Perinatal outcomes, including fetal growth restriction, fetal distress, low birth weight, intrauterine fetal death, and malformation. The incidence of adverse pregnancy outcomes and perinatal complications was compared between women in the first trimester and second trimester with isolated hypothyroxinemia. Results: There were no significant differences in the incidence rates of adverse maternal outcomes and perinatal complications between patients in the first and second trimesters with isolated hypothyroxinemia. Conclusion: The results of this study indicate that isolated hypothyroidism does not increase the incidence of adverse maternal outcomes and perinatal complications. |
| Databáze: | OpenAIRE |
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