Association between genetic polymorphisms in cytokine genes and recurrent miscarriage – a meta-analysis
| Autor: | Saša Ostojić, Andrej Kastrin, Nina Pereza, Borut Peterlin, Igor Medica |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Abortion
Habitual Genotype cytokines gene meta-analysis polymorphism recurrent miscarriage Biology Pregnancy Polymorphism (computer science) Recurrent miscarriage Genetic model Odds Ratio medicine Humans Genetic Predisposition to Disease Gene Genetic association Genetics Polymorphism Genetic Interleukin-6 Tumor Necrosis Factor-alpha Obstetrics and Gynecology Odds ratio medicine.disease Interleukin-10 Reproductive Medicine Case-Control Studies Meta-analysis Cytokines Female Genome-Wide Association Study Developmental Biology |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1472-6483 |
| DOI: | 10.1016/s1472-6483(10)60176-9 |
| Popis: | A meta-analysis of association studies was performed to assess whether the reported genetic polymorphisms in cytokine genes are risk factors for recurrent miscarriage (RM). The electronic PubMed database was searched for case– control studies on immunity-related genes in RM. Investigations of a single polymorphism/gene involvement in RM reported more than five times were selected. Aggregating data from seven case-control studies on − 308/tumour necrosis factor-α polymorphism, the odds ratio (OR) for RM was 1.1 (0.87− 1.39) if the polymorphism was considered under a dominant genetic model. In six studies on − 1082/interleukin-10 (IL-10) polymorphism, the OR under a dominant model was 0.76 (0.58− 0.99), and under a recessive model the OR was 0.90 (0.71− 1.15). In five case– control studies on − 174/IL-6 polymorphism, the OR for RM under a recessive model was 1.29 (0.69− 2.40). The results show a statistically significant association with RM for the − 1082/IL-10 genotype. |
| Databáze: | OpenAIRE |
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