Intracellular Calcium and Sodium-Lithium Countertransport in Type 2 Diabetic Patients with and without Albuminuria
| Autor: | Günter Kraatz, Dirk Vogelgesang, Sybille Gruska, Rainer Rettig, Henry Völzke, Wolfgang Kerner |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Intracellular Fluid Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Stimulation Type 2 diabetes Lithium Calcium in biology Diabetic nephropathy Basal (phylogenetics) Endocrinology Risk Factors Internal medicine Diabetes mellitus medicine Albuminuria Humans Diabetic Nephropathies Cells Cultured Aged Aged 80 and over Ion Transport business.industry Sodium Middle Aged medicine.disease Diabetes Mellitus Type 2 Population study Calcium Female medicine.symptom business |
| Zdroj: | Endocrine Journal. 53:773-781 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.k06-065 |
| Popis: | Increased intracellular calcium concentrations ([Ca(2+)](i)) and enhanced sodium-lithium countertransport (Na/Li CT) activities may play a role in the development of diabetic complications such as diabetic nephropathy. The present study was designed to test the hypothesis that albuminuria in patients with type 2 diabetes is associated with increased [Ca(2+)](i) in response to stimulation with platelet-activating factor (PAF) or with enhanced Na/Li CT activities. The study population comprised 203 type 2 diabetic patients. Albuminuria was defined as an albumin excretion rate exceeding 30 mg/d (117 cases). PAF-evoked rises in [Ca(2+)](i) and Na/Li CT activities were determined in Epstein-Barr-virus-immortalized lymphoblasts. Albuminuria was related to high stimulated [Ca(2+)](i) but not to high basal [Ca(2+)](i). The association was independent of age, sex and several non-diabetes related confounders, but depended on diabetes-related factors, such as the duration of diabetes. The risk of albuminuria was highest in subjects with high [Ca(2+)](i) who reported a diabetes duration of < or =10 years. There was no association between Na/Li CT activities and albuminuria. The present results support the hypothesis that albuminuria in type 2 diabetic patients is associated with a primary defect in intracellular calcium homeostasis. The association between stimulated [Ca(2+)](i) and albuminuria is most prominent in early diabetes. |
| Databáze: | OpenAIRE |
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