High prevalence and resistance rates of Mycoplasma genitalium among patients visiting two sexually transmitted infection clinics in the Netherlands
| Autor: | Alje P. van Dam, David J. Hetem, Roel H. T. Nijhuis, Joyce F. Braam, Martijn S. van Rooijen, Jean-Marie Brand, Sophie Kuizenga Wessel, Clarissa E. Vergunst, Mary Berns, Sylvia M. Bruisten |
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| Přispěvatelé: | Dermatology, Graduate School, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Finance |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
macrolide resistance Prevalence Cervicitis Mycoplasma genitalium Dermatology urologic and male genital diseases medicine.disease_cause Azithromycin Men who have sex with men 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine Pelvic inflammatory disease medicine Pharmacology (medical) Urethritis 030212 general & internal medicine sexual transmitted diseases azithromycin 0303 health sciences biology 030306 microbiology business.industry Public Health Environmental and Occupational Health bacterial infections and mycoses medicine.disease biology.organism_classification female genital diseases and pregnancy complications Infectious Diseases Neisseria gonorrhoeae business medicine.drug |
| Zdroj: | International journal of STD & AIDS, 32(9), 837-844. SAGE Publications Ltd International Journal of STD and AIDS, 32(9), 837-844. SAGE Publications Ltd Hetem, D J, Kuizenga Wessel, S, Bruisten, S M, Braam, J F, van Rooijen, M S, Vergunst, C E, Nijhuis, R H, Berns, M, Brand, J-M & van Dam, A P 2021, ' High prevalence and resistance rates of Mycoplasma genitalium among patients visiting two sexually transmitted infection clinics in the Netherlands ', International Journal of STD and AIDS, vol. 32, no. 9, pp. 837-844 . https://doi.org/10.1177/0956462421999287 |
| ISSN: | 1758-1052 0956-4624 |
| Popis: | Mycoplasma genitalium is a well-known cause of urethritis in men and has been associated with cervicitis, pelvic inflammatory disease, and adverse obstetric outcomes in women. In this cross-sectional study, we determined the current prevalence of M. genitalium infection and the rate of macrolide resistance in M. genitalium isolates, in patients visiting two large Dutch sexually transmitted infection (STI) clinics, to evaluate whether the recommendations in Dutch guidelines should be revised. In addition, risk factors for M. genitalium were identified. In total, 3225 patients were included. M. genitalium prevalence rates were 13.8% for all patients; 20.1% for men who have sex with men, 8.2% for men who have sex with women, and 12.6% for women. Macrolide resistance-associated mutations were detected in 66% of the patients infected with M. genitalium. Age, educational level, country of origin, number of sexual partners, HIV-positivity, infection with Neisseria gonorrhoeae, and urethral symptoms in men were independently associated with M. genitalium infection. In conclusion, we found very high prevalence rates and macrolide resistance rates of M. genitalium in patients visiting STI clinics. |
| Databáze: | OpenAIRE |
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