Cholinergic deafferentation of the hippocampus causes non-temporally graded retrograde amnesia in an odor discrimination task
| Autor: | Joseph L. Cheatwood, Philip A. Blankenship, Jenny R. Köppen, Douglas G. Wallace, Ashley A. Blackwell, Megan L. Sieg, Sarah L. Stuebing |
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| Rok vydání: | 2016 |
| Předmět: |
Memory
Long-Term Cholinergic Agents Hippocampus Mnemonic Hippocampal formation Task (project management) Discrimination Learning 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Animals Dementia Rats Long-Evans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Discrimination learning Memory Disorders 05 social sciences Antibodies Monoclonal Retrograde amnesia medicine.disease Saporins Rats Odorants Ribosome Inactivating Proteins Type 1 Cholinergic Amnesia Retrograde Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 299:97-104 |
| ISSN: | 0166-4328 |
| Popis: | Dementia of the Alzheimer's type (DAT) is a neurodegenerative disorder marked by loss of hippocampal cholinergic tone and significant memory impairments, specifically for memories acquired prior to disease onset. The nature of this relationship, however, remains debated. The current study used the string pulling task to evaluate the temporal effects of odor discrimination learning in animals with selective cholinergic lesions to determine the role of the septohippocampal cholinergic system in mnemonic function. Rats with 192-IgG-Saporin lesions to the medial septum had a higher number of correct responses in the reversal training when compared to sham rats, suggesting an inability to retrieve the previously learned discrimination; however, no temporal gradient was observed. Furthermore, there were no group differences when learning a novel odor discrimination, demonstrating the ability for all rats to form new memories. These results establish a role for the cholinergic medial septum projections in long-term memory retrieval. The current study provides a behavioral assessment technique to investigate factors that influence mnemonic deficits associated with rodent models of DAT. |
| Databáze: | OpenAIRE |
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