Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively
| Autor: | Chun Heng Kuo, Chung-Yi Yang, Jung-Nan Wei, Hung-Yuan Li, Shu-Huei Wang, Hung Tsung Wu, Horng Yih Ou, Mei Kuei Lee, Cyue Huei Hua, Kang Chih Fan, Ching Hsiang Hsiao |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Glucose uptake Taiwan Medicine (miscellaneous) 030209 endocrinology & metabolism Gastroenterology Prediabetic State 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Longitudinal Studies Obesity 030212 general & internal medicine Prediabetes Nutrition and Dietetics business.industry nutritional and metabolic diseases Middle Aged medicine.disease Up-Regulation C-Reactive Protein Diabetes Mellitus Type 2 Hyperglycemia Female Adiponectin Amine Oxidase (Copper-Containing) Animal studies business Cell Adhesion Molecules Body mass index Cohort study |
| Zdroj: | International Journal of Obesity. 43:512-522 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/s41366-018-0172-4 |
| Popis: | Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ≥ 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ≥ 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ≥ 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. sVAP-1 was higher in subjects with prediabetes (p |
| Databáze: | OpenAIRE |
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