Isolation and identification of beta-hydroxyethylaprophen: a urinary metabolite of aprophen in rats
| Autor: | Peter K. Chiang, Haim Leader, Lawrence R. Phillips, Nesbitt D. Brown |
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| Rok vydání: | 1991 |
| Předmět: |
Drug
Male Chromatography Phenylpropionates medicine.drug_class Urinary system Metabolite media_common.quotation_subject Administration Oral Parasympatholytics Rats Inbred Strains General Chemistry Metabolism Urine Parasympatholytic Rats chemistry.chemical_compound chemistry Oral administration Anticholinergic medicine Animals media_common Chromatography Liquid |
| Zdroj: | Journal of chromatography. 563(2) |
| Popis: | The metabolism of the anticholinergic drug aprophen was studied in rats after oral administration via stomach intubation. β-Hydroxyethylaprophen, a major urinary metabolite of aprophen, was isolated and identified by normal-phase high-performance liquid chromatography and electron ionization mass spectrometry. More than 22% of the parent drug was recovered and quantified over a 72-h collection period. Results show that 2,2-diphenylpropionic acid, another major metabolite of aprophen which lacks anti-cholinergic properties, was also isolated and identified in this study. Experiments are currently underway to synthesize and test the anticholinergic properties of β-hydroxyethylaprophen in mammals. |
| Databáze: | OpenAIRE |
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