Prognostic value of leucine/phenylalanine ratio as an amino acid profile of heart failure
| Autor: | Yuki Kimura, Yoshifumi Awaji, Sayano Kondo, Masafumi Shimojo, Toshiaki Kato, Toru Kondo, Daisuke Tanimura, Etsuo Iwata, Toyoaki Murohara, Takahiro Okumura, Hiroaki Hiraiwa, Shingo Kazama, Hiroaki Sano, Soichiro Aoki, Sumio Yamada, Toshikazu Ishihara, Yasunori Kanzaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Phenylalanine 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Leucine Valine Internal medicine Aromatic amino acids medicine Humans 030212 general & internal medicine Tyrosine Aged Retrospective Studies Aged 80 and over Heart Failure business.industry Area under the curve Middle Aged Prognosis medicine.disease Endocrinology ROC Curve chemistry Heart failure Female Isoleucine Cardiology and Cardiovascular Medicine business Amino Acids Branched-Chain Biomarkers Follow-Up Studies |
| Zdroj: | Heart and Vessels. 36:965-977 |
| ISSN: | 1615-2573 0910-8327 |
| DOI: | 10.1007/s00380-020-01765-z |
| Popis: | Heart failure (HF) causes a hypercatabolic state that enhances the catabolic activity of branched-chain amino acids (BCAA; leucine, isoleucine, and valine) in the heart and skeletal muscles and reduces protein synthesis in the liver. Consequently, free plasma aromatic amino acids (AAA, tyrosine and phenylalanine) are increased. To date, we have reported the prognostic value of the BCAA/AAA ratio (Fischer’s ratio) in patients with HF. However, the leucine/phenylalanine ratio, which is a simpler index than the Fischer’s ratio, has not been examined. Therefore, the prognostic value of the leucine/phenylalanine ratio in patients with HF was investigated. Overall 157 consecutive patients hospitalized for worsening HF (81 men, median age 78 years) were enrolled in the study. Plasma amino acid levels were measured when the patients were stabilized at discharge. Cardiac events were defined as a composite of cardiac death and hospitalization for worsening HF. A total of 46 cardiac events occurred during the median follow-up period of 238 (interquartile range 93–365) days. The median leucine/phenylalanine ratio was significantly lower in patients with cardiac events than in those without cardiac events (1.4 vs. 1.8, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink