Selective antibacterial effects of mixed ZnMgO nanoparticles
| Autor: | Bernard Delmas, Jasmina Vidic, Ronan Le Goffic, Aurore Vidy, Francia Haque, Slavica Stankic, Danica Ciric, Jacques Jupille |
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| Přispěvatelé: | Unité de recherche Virologie et Immunologie Moléculaires (VIM), Institut National de la Recherche Agronomique (INRA), Oxydes en basses dimensions (INSP-E9), Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institute for Biological Research Sinisa Stankovic [Belgrade] (IBISS), University of Belgrade [Belgrade], Pavle Savic program, EGIDE, French Ministere des Affaires etrangeres, Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Chemistry(all) Nanoparticle Bioengineering Nanotechnology 02 engineering and technology Bacterial growth 010402 general chemistry 01 natural sciences ZnMgO HeLa Materials Science(all) Nanoparticle toxicity Modelling and Simulation medicine B. subtilis General Materials Science [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat] Cell damage biology E. coli General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification medicine.disease Atomic and Molecular Physics and Optics 0104 chemical sciences 3. Good health Transmission electron microscopy Metal oxide nanoparticles Modeling and Simulation Mixed oxide Antibacterial activity 0210 nano-technology Bacteria Research Paper Nuclear chemistry |
| Zdroj: | Journal of Nanoparticle Research Journal of Nanoparticle Research, Springer Verlag, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩ Journal of Nanoparticle Research, 2013, 15 (5), pp.1595. ⟨10.1007/s11051-013-1595-4⟩ |
| ISSN: | 1388-0764 1572-896X |
| Popis: | Antibiotic resistance has impelled the research for new agents that can inhibit bacterial growth without showing cytotoxic effects on humans and other species. We describe the synthesis and physicochemical characterization of nanostructured ZnMgO whose antibacterial activity was compared to its pure nano-ZnO and nano-MgO counterparts. Among the three oxides, ZnO nanocrystals-with the length of tetrapod legs about 100 nm and the diameter about 10 nm-were found to be the most effective antibacterial agents since both Gram-positive (B. subtilis) and Gram-negative (E. coli) bacteria were completely eradicated at concentration of 1 mg/mL. MgO nanocubes (the mean cube size similar to 50 nm) only partially inhibited bacterial growth, whereas ZnMgO nanoparticles (sizes corresponding to pure particles) revealed high specific antibacterial activity to Gram-positive bacteria at this concentration. Transmission electron microscopy analysis showed that B. subtilis cells were damaged after contact with nano-ZnMgO, causing cell contents to leak out. Our preliminary toxicological study pointed out that nano-ZnO is toxic when applied to human HeLa cells, while nano-MgO and the mixed oxide did not induce any cell damage. Overall, our results suggested that nanostructured ZnMgO, may reconcile efficient antibacterial efficiency while being a safe new therapeutic for bacterial infections. Pavle Savic program; EGIDE; French Ministere des Affaires etrangeres |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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