| Autor: |
Matthew T. Rondina, Amanda I Pacheco, Robert Hunter, Franklin Staback, Bismark Madera, C. Christian Yost, Jesse W. Rowley, Jessica Morales-Ortíz, A. Valance Washington, Humberto Ortiz-Zuazaga, Alex St John, Nahomy Ledesma, Gerónimo Maldonado-Martínez, Cheyanne Croft, Junmei Chen, Victoria Deal, José A. López, Angelia D. Gibson, Fiorella Reyes |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Blood. 132:2495-2505 |
| ISSN: |
1528-0020
0006-4971 |
| Popis: |
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)–like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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