Perinatal outcomes in pregnancies complicated by type 1 diabetes mellitus
| Autor: | Dalong Zhu, Zhijuan Ge, Jun Hu, Yan Bi, Jing Lu, Qianyue Xu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty China endocrine system diseases Endocrinology Diabetes and Metabolism Pregnancy in Diabetics 030209 endocrinology & metabolism Glycemic Control 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Pregnancy Diabetes mellitus medicine Humans Retrospective Studies Type 1 diabetes 030219 obstetrics & reproductive medicine business.industry Obstetrics Infant Newborn Pregnancy Outcome nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Gestational diabetes Diabetes Gestational Diabetes Mellitus Type 1 Female business |
| Zdroj: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 36(10) |
| ISSN: | 1473-0766 |
| Popis: | The aim of this study was to explore the risk of perinatal outcomes in pre-gestational type 1 diabetes mellitus (T1DM) compared to gestational diabetes mellitus (GDM) and pregnancy without diabetes and to examine the association of glycemic level of third-trimester gestation with perinatal outcomes in T1DM. We included 69 pre-gestational T1DM, 1398 cases of GDM, and 1304 control pregnancies and collected data regarding demographics, obstetric, and perinatal outcomes from the hospital discharge database. Relative to the pregnancies without diabetes, women with T1DM encountered increasing risk of polyhydramnios, preterm delivery, and cesarean section. These adverse outcomes were also common in GDM, although with relatively lower adjusted ORs. The weights of babies delivered by women with T1DM were more intend to be large for gestational age, as well as to be less than 2.5 kg relative to those without diabetes. Poorly controlled hemoglobin A1c in late pregnancy was significantly associated with an increased risk of preterm birth in T1DM (adjusted odds ratio 2.01, 95%confidence interval 1.1-3.6). Women with T1DM have considerably increased risks of adverse perinatal outcomes, which appear more prevalent than the perinatal outcomes in women with GDM. Thus, a specific routine is required for pregnancy in T1DM to improve the glycemic control and obstetric care. |
| Databáze: | OpenAIRE |
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