Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura
| Autor: | Ronald E. Domen, Arthur B. Abt, Andrew S. Freiberg, Deborah Kees-Folts |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Nephrology
Adult medicine.medical_specialty Adolescent medicine.medical_treatment Rho(D) Immune Globulin Gastroenterology Hemolysis Rho(D) immune globulin hemic and lymphatic diseases Immunopathology Internal medicine medicine Humans Child Dialysis Acute tubular necrosis Aged Aged 80 and over business.industry Acute kidney injury Infant Acute Kidney Injury Middle Aged medicine.disease Thrombocytopenic purpura Purpura Thrombocytopenic Pediatrics Perinatology and Child Health Immunology Female business medicine.drug Kidney disease |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 17(2) |
| ISSN: | 0931-041X |
| Popis: | Idiopathic thrombocytopenic purpura (ITP) is a disorder of rapid destruction of antibody-coated platelets. Anti-D immune globulin has been used for treatment of ITP in the United States since 1995. Initial studies identified no significant side effects of treatment. However, a recent report highlighted occasional episodes of intravascular hemolysis after anti-D immune globulin. We describe two children with ITP who developed acute renal failure (ARF) after treatment with anti-D immune globulin and also analyze ten additional cases of ARF reported to the manufacturer, Cangene Corporation, through postmarketing surveillance. All episodes of ARF were associated with intravascular hemolysis. Four patients required dialysis. Patient age ranged from 1 to 82 years, but those requiring dialysis were all under age 15 years. Several patients with ARF had preexisting creatinine elevation. Three of the patients with ARF had serologic evidence of acute Epstein-Barr virus (EBV) infection. Renal biopsy in one patient showed acute tubular necrosis, with findings consistent with pigment nephropathy. Anti-D immune globulin, used to treat ITP, may be associated with intravascular hemolysis and resultant ARF. Renal function should be monitored in patients with evidence of intravascular hemolysis. Children and adolescents may have increased risk of ARF requiring dialysis. |
| Databáze: | OpenAIRE |
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