Hepatitis C virus co-infection and sexual risk behaviour are associated with a high homocysteine serum level in HIV-infected patients
| Autor: | Bennasar M, Bernardino Roca, Ferrero Ja, del Monte Mc, Resino E |
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| Rok vydání: | 2012 |
| Předmět: |
hepatitis C virus
Adult Male medicine.medical_specialty Homocysteine Hepatitis C virus Sexual Behavior Population HIV Infections Hepacivirus medicine.disease_cause Gastroenterology chemistry.chemical_compound Folic Acid Risk-Taking Risk Factors Internal medicine Medicine Outpatient clinic Humans Vitamin B12 Family history education education.field_of_study business.industry Coinfection HIV homocysteine General Medicine medicine.disease Hepatitis C Vitamin B 12 Blood pressure Cross-Sectional Studies chemistry Cardiovascular Diseases Immunology Female HIV-infected patients business |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1424-3997 |
| Popis: | BACKGROUND AND AIMS: A better understanding of the relationship of homocysteine with cardiovascular risk factors is needed. The objectives of this study were to assess the serum level of homocysteine in HIV-infected patients and to analyse the possible association of increased levels of the amino acid with cardiovascular risk factors, demographic and clinical characteristics of participants. METHODS: Cross-sectional study carried out as a supplementary task to the usual controls necessary in HIV-infected patients in the outpatient clinic of the Hospital General of Castellon, Spain. For two consecutive visits the demographic, clinical and HIV-related characteristics and blood analyses results were obtained for each participant. Homocysteine serum level was documented and the possible association of the amino acid with all the other study variables was assessed with a multiple linear regression analysis. RESULTS: A total of 145 patients were included. The mean homocysteine serum level of all participants was 11.9 ± 5.9 µmol/L. A total of 54 patients (37%) presented homocysteine serum levels higher than the upper limit of normal. An association was found between higher homocysteine serum level and the following variables: family history of early coronary disease (P = 0.027), sexual HIV risk behaviour (P = 0.016), hepatitis C virus co-infection (P = 0.002), higher height (P = 0.002), higher diastolic blood pressure (P = 0.049), lower serum level of folic acid (P |
| Databáze: | OpenAIRE |
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