Mycophenolate mofetil for the treatment of acute and chronic GVHD in bone marrow transplant patients
| Autor: | Nadezda Basara, M Rudolphi, E Römer, Axel A. Fauser, WI Blau, S Günzelmann, H Sanchez, D Kirsten, M Bischoff |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Prednisolone Graft vs Host Disease Human leukocyte antigen Gastroenterology immune system diseases hemic and lymphatic diseases Immunopathology Acute lymphocytic leukemia Internal medicine medicine Humans Bone Marrow Transplantation Transplantation Chemotherapy business.industry Anemia Hematology Leukopenia Middle Aged Mycophenolic Acid Ciclosporin medicine.disease surgical procedures operative medicine.anatomical_structure Immunology Acute Disease Chronic Disease Cyclosporine Female Bone marrow Complication business Immunosuppressive Agents medicine.drug |
| Zdroj: | Bone marrow transplantation. 22(1) |
| ISSN: | 0268-3369 |
| Popis: | The efficacy and safety of mycophenolate mofetil (MMF) in combination with CsA and prednisolone for the treatment of acute and chronic GVHD (aGVHD and cGVHD, respectively) after BMT and PBSCT from HLA-mismatched and -matched donors was evaluated in an open single center trial. Twenty-four patients, 17-48 years of age, with acute (n = 17) and chronic GVHD (n = 7) were treated with 2 g MMF daily in addition to CsA and prednisolone. Overall grade improvement of aGVHD was found in 11 of 17 (65%) patients treated with MMF. MMF therapy in the treatment of cGVHD led to moderate improvement in three of six patients with limited cGVHD. The most common adverse hematologic events of MMF were leukopenia (n = 6), anemia (n = 4) and thrombocytopenia (n = 3). Hematological adverse events were not severe and did not require the discontinuation of MMF. In this preliminary study, we have shown that MMF can be used safely for the treatment of aGVHD. In addition, the MMF therapy resulted in significant dose reduction of prednisolone for the treatment of GVHD. |
| Databáze: | OpenAIRE |
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