Seroepidemiological study of rubella in Vojvodina, Serbia: 24 years after the introduction of the MMR vaccine in the national immunization programme

Autor: Ivana Hrnjaković Cvjetković, Vesna Milosevic, Aleksandra Patic, Snežana Medić, Vladimir Petrovic, Mirjana Strbac, Mioljub Ristic
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
RNA viruses
Male
Pediatrics
Viral Diseases
National Health Programs
Physiology
medicine.disease_cause
Pathology and Laboratory Medicine
Antibodies
Viral
Biochemistry
Geographical Locations
0302 clinical medicine
Seroepidemiologic Studies
Immune Physiology
Medicine and Health Sciences
Public and Occupational Health
030212 general & internal medicine
Child
Vaccines
Multidisciplinary
Immune System Proteins
Incidence (epidemiology)
Incidence
Age Factors
Rubella virus
Middle Aged
Vaccination and Immunization
Vaccination
Europe
MMR vaccine
Infectious Diseases
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
Medicine
Female
Pathogens
Serbia
Research Article
Rubella Virus
Adult
medicine.medical_specialty
Adolescent
Science
030106 microbiology
Immunology
Rubella
Microbiology
Mass Vaccination
Virus
Antibodies
Togaviruses
03 medical and health sciences
Virology
Infectious disease control
medicine
Humans
Microbial Pathogens
business.industry
Viral vaccines
Immunity
Organisms
Outbreak
Biology and Life Sciences
Proteins
Infant
medicine.disease
Immunization
Age Groups
Immunoglobulin G
People and Places
Population Groupings
Preventive Medicine
business
Measles-Mumps-Rubella Vaccine
Zdroj: PLoS ONE, Vol 15, Iss 1, p e0227413 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Although rubella is usually a mild childhood disease, this infection in early pregnancy poses a serious problem due to its teratogenic effect. The goal of interrupted circulation and elimination of rubella virus was achieved in many countries in the world. The aim of this study was to determine the status of rubella immunity in Vojvodina and evaluate Serbia's progress toward this goal. A total of 3404 residual serum samples from patients of all ages (1 to 84 years) were included in the study. Samples were collected between May 2015 and December 2017 in Vojvodina. Rubella IgG antibodies were determined using an indirect chemiluminescent immunoassay. Percentage of participants seropositive for rubella antibodies was 92.9% in the entire sample. The highest number of seronegatives was in the youngest (1 year) age group (44.7%), followed by the group aged 24-49 (6.4%) and 2-11 years (6.2%). The absence of a higher percentage of children with protective anti-rubella antibodies in the group aged 2-11 can be explained by a lower immunization coverage during certain years. Participants in the group aged 24-49 were born during the pre-vaccination period with lower rubella incidence, leading to the conclusion that not all individuals of that age came into a contact with the virus. Comparing levels of anti-rubella IgG antibodies of seropositive males and females of different ages reveals that the immunity after a contact with the virus and a previously acquired infection is stronger than the immunity after the vaccination. Although the incidence rate of rubella in Vojvodina has been low for the last ten years, there is still a risk of an outbreak due to a decrease in immunization coverage. This study shows that the percentage of susceptible individuals is high, especially considering women aged 24-49, and that additional ("catch-up") immunization is required.
Databáze: OpenAIRE
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