Seroepidemiological study of rubella in Vojvodina, Serbia: 24 years after the introduction of the MMR vaccine in the national immunization programme
Autor: | Ivana Hrnjaković Cvjetković, Vesna Milosevic, Aleksandra Patic, Snežana Medić, Vladimir Petrovic, Mirjana Strbac, Mioljub Ristic |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
RNA viruses Male Pediatrics Viral Diseases National Health Programs Physiology medicine.disease_cause Pathology and Laboratory Medicine Antibodies Viral Biochemistry Geographical Locations 0302 clinical medicine Seroepidemiologic Studies Immune Physiology Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine Child Vaccines Multidisciplinary Immune System Proteins Incidence (epidemiology) Incidence Age Factors Rubella virus Middle Aged Vaccination and Immunization Vaccination Europe MMR vaccine Infectious Diseases Medical Microbiology Viral Pathogens Child Preschool Viruses Medicine Female Pathogens Serbia Research Article Rubella Virus Adult medicine.medical_specialty Adolescent Science 030106 microbiology Immunology Rubella Microbiology Mass Vaccination Virus Antibodies Togaviruses 03 medical and health sciences Virology Infectious disease control medicine Humans Microbial Pathogens business.industry Viral vaccines Immunity Organisms Outbreak Biology and Life Sciences Proteins Infant medicine.disease Immunization Age Groups Immunoglobulin G People and Places Population Groupings Preventive Medicine business Measles-Mumps-Rubella Vaccine |
Zdroj: | PLoS ONE, Vol 15, Iss 1, p e0227413 (2020) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Although rubella is usually a mild childhood disease, this infection in early pregnancy poses a serious problem due to its teratogenic effect. The goal of interrupted circulation and elimination of rubella virus was achieved in many countries in the world. The aim of this study was to determine the status of rubella immunity in Vojvodina and evaluate Serbia's progress toward this goal. A total of 3404 residual serum samples from patients of all ages (1 to 84 years) were included in the study. Samples were collected between May 2015 and December 2017 in Vojvodina. Rubella IgG antibodies were determined using an indirect chemiluminescent immunoassay. Percentage of participants seropositive for rubella antibodies was 92.9% in the entire sample. The highest number of seronegatives was in the youngest (1 year) age group (44.7%), followed by the group aged 24-49 (6.4%) and 2-11 years (6.2%). The absence of a higher percentage of children with protective anti-rubella antibodies in the group aged 2-11 can be explained by a lower immunization coverage during certain years. Participants in the group aged 24-49 were born during the pre-vaccination period with lower rubella incidence, leading to the conclusion that not all individuals of that age came into a contact with the virus. Comparing levels of anti-rubella IgG antibodies of seropositive males and females of different ages reveals that the immunity after a contact with the virus and a previously acquired infection is stronger than the immunity after the vaccination. Although the incidence rate of rubella in Vojvodina has been low for the last ten years, there is still a risk of an outbreak due to a decrease in immunization coverage. This study shows that the percentage of susceptible individuals is high, especially considering women aged 24-49, and that additional ("catch-up") immunization is required. |
Databáze: | OpenAIRE |
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