Pulmonary manifestations in Egyptian patients with systemic sclerosis
| Autor: | Sherin Mohamed Hosny Hamza, Caroline S. Morad, Ahmed A. Abd Alkader, Eman A. Hafez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Vital capacity medicine.medical_specialty Pathology Skin thickness score Interstitial lung disease Nailfold capillary microscopy Gastroenterology Pulmonary function testing Pulmonary hypertension 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Rheumatology Internal medicine medicine In patient Honeycombing 030203 arthritis & rheumatology business.industry respiratory system medicine.disease respiratory tract diseases 030228 respiratory system Cohort Systemic sclerosis business lcsh:RC581-607 |
| Zdroj: | Egyptian Rheumatologist, Vol 40, Iss 1, Pp 39-44 (2018) |
| ISSN: | 1110-1164 |
| Popis: | Aim of the work: To study the occurrence of interstitial lung disease (ILD) and pulmonary hypertension (PH) in a cohort of Egyptian systemic sclerosis (SSc) patients and their relation to clinical variables. Patients and methods: Thirty SSc patients underwent pulmonary function tests (PFTs), plain chest X-ray and chest high-resolution computed tomography to assess parenchymal abnormality and maximum fibrosis score (Fibmax). Transthoracic echocardiography to screen for evidence of pH. Nailfold capillary microscopy examination for recognizing nailfold capillary abnormalities and staging, skin thickness assessment by modified Rodnan's skin score (MRSS). Results: The mean age of the patients was 40.97 ± 12.63 years; 22 females and 8 males and disease duration was 9.65 ± 8.18 years. 17(56.7%) patients had diffuse cutaneous systemic sclerosis (dcSSc) and 13(43.3%) localized cutaneous (lcSSc). All patients showed restriction in the PFTs. ILD was present in 83% and PH in 17%; ground-glass opacity in 83.3%, septal thickening in 56.7%, honeycombing in 43.3%, bronchiolectasis in 23.3% and consolidations in 20% of the patients. ILD was significantly more in dcSSc than in lcSSc (p = 0.025). PH was present in 29.4% of the dcSSc patients but in none of the lcSSc patients. MRSS was significantly higher in patients with pulmonary affection than those without (p = 0.016) and in patients with ILD and PH than those with ILD alone. A significant correlation was found between the Fibmax and MRSS (r = 0.87, p 11 years, forced vital capacity (FVC) 20. Conclusion: ILD is a frequent finding and PH is common in SSc patients especially the dcSSc subtypes. Disease duration, decline in FVC and increased skin thickness are associated with an increased risk of ILD. |
| Databáze: | OpenAIRE |
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