Correlation of Heat Shock Protein 70 Expression with Estrogen Receptor Levels in Invasive Human Breast Cancer
| Autor: | Akira Okazaki, Yoshiki Watanabe, Toshihiko Mikami, Noriyuki Sato, Kokichi Kikuchi, Koichi Hirata, Yutaka Okazaki, Michio Mori, Shuji Takahashi, Minoru Okazaki, Takashi Sato, Asaishi K, Eimei Narimatsu |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Receptor ErbB-2 medicine.drug_class Mammary gland Estrogen receptor Breast Neoplasms medicine.disease_cause Breast cancer Proto-Oncogene Proteins Internal medicine Heat shock protein medicine Humans Epidermal growth factor receptor Heat-Shock Proteins biology Cancer General Medicine Middle Aged medicine.disease Immunohistochemistry ErbB Receptors Endocrinology medicine.anatomical_structure Receptors Estrogen Estrogen Cancer research biology.protein Female Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | American Journal of Clinical Pathology. 101:519-525 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/101.4.519 |
| Popis: | The authors studied the role of 70-Kd heat shock protein (HSP70) in the progression of breast cancer by examining the correlation between the expression of HSP70 and epidermal growth factor receptor, c- erb B-2, p53, and estrogen receptor in 124 cases of invasive primary human breast cancers. Positivity of an anti-HSP70 monoclonal antibody, C92, was closely associated with the elevation of estrogen receptor ( P < .008), whereas it inversely correlated with the expression of p53 ( P < .01). In addition, the expression of HSP70 correlated inversely with the expression of epidermal growth factor receptor, although the correlation was not statistically significant ( P = .06). These results suggest that the expression of HSP70 plays a role in the progression of human breast cancer. |
| Databáze: | OpenAIRE |
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