Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients
| Autor: | Risteard O’Laoide, John Ryan, Micheal Evanoff, Niall Tubridy, Patrick C. Brennan, Roisin Lonergan, Jonathan P. McNulty |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Multiple Sclerosis Internuclear ophthalmoplegia Diagnostic Techniques Ophthalmological Fluid-attenuated inversion recovery Sensitivity and Specificity symbols.namesake Ocular Motility Disorders Oculomotor Nerve Humans Medicine Radiology Nuclear Medicine and imaging Neuroradiology Observer Variation medicine.diagnostic_test business.industry Multiple sclerosis Area under the curve Reproducibility of Results Signal Processing Computer-Assisted Magnetic resonance imaging Middle Aged Image Enhancement medicine.disease Medial longitudinal fasciculus Diffusion Tensor Imaging Bonferroni correction symbols Female Neurology (clinical) business Nuclear medicine |
| Zdroj: | Clinical Neuroradiology. 25:233-239 |
| ISSN: | 1869-1447 1869-1439 |
| DOI: | 10.1007/s00062-014-0295-5 |
| Popis: | The purpose of this study was to investigate the diagnostic efficacy of a range of conventional magnetic resonance imaging (MRI) pulse sequences in the identification of internuclear ophthalmoplegia (INO) caused by medial longitudinal fasciculus (MLF) lesions in multiple sclerosis patients using a receiver-operating characteristic (ROC) methodology. A total of 15 clinically confirmed INO and 15 control subjects underwent conventional MRI at 1.5 T consisting of T2-weighted, proton density (PD)-weighted, and fluid-attenuated inversion recovery (FLAIR) sequences, following full institutional approval. A free-response, multiple-reader multiple-case design ROC study was used to evaluate the diagnostic efficacy of each sequence. All imaging sequences were evaluated by 10 board-certified neuroradiologists. Area under the curve (AUC), sensitivity, and specificity were analysed statistically for all three pulse sequences using repeated-measures analyses of variance and post-test analysis using Bonferroni’s multiple comparison test of differences. No significant AUC differences were found between the three sequences (p = 0.0697), with T2 recording the highest AUC (0.8346). Sensitivity differences between PD (0.7927) and FLAIR (0.6329) were significant (p |
| Databáze: | OpenAIRE |
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