Antitrichomonal activity of mesoionic thiazolo[3,2-a]pyridines
| Autor: | Thomas R. Matthews, Keith A. M. Walker, Eric Brian Sjogren |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Chemical Phenomena
Pyridines Stereochemistry Trichomonas Infections Pyridinium Compounds Structure-Activity Relationship chemistry.chemical_compound In vivo Cricetinae Metronidazole Drug Discovery Animals chemistry.chemical_classification Mesocricetus Bicyclic molecule Chemistry Mesoionic Electron acceptor In vitro Thiazoles Trichomonas Molecular Medicine Hydroxide Female Pyridinium |
| Zdroj: | Journal of Medicinal Chemistry. 28:1673-1679 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | Screening of mesoionic compounds as potential electron acceptors by analogy with metronidazole led to the finding of in vitro antitrichomonal activity for anhydro-2-phenyl-3-hydroxythiazolo [3,2-a]pyridinium hydroxide (1). In a series of analogues, potent in vitro activity was found to be associated with amino substitution; however, such activity was dependent on specific structural features and not on the reduction potential. The most active compounds showed only poor in vivo activity. |
| Databáze: | OpenAIRE |
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