A quantitative genetic analysis of intermediate asthma phenotypes

Autor: Vibeke Backer, Kirsten Ohm Kyvik, Manuel A. R. Ferreira, Mogens Fenger, Simon Francis Thomsen
Rok vydání: 2009
Předmět:
Zdroj: Thomsen, S F, Ferreira, M A R, Kyvik, K O, Fenger, M & Backer, V 2009, ' A quantitative genetic analysis of intermediate asthma phenotypes ', Allergy. European Journal of Allergy and Clinical Immunology, vol. 64, no. 3, pp. 427-430 . https://doi.org/10.1111/j.1398-9995.2008.01850.x
ISSN: 1398-9995
0105-4538
Popis: Udgivelsesdato: 2009-Jan-27 Aim: To study the relative contribution of genetic and environmental factors to the correlation between exhaled nitric oxide (FeNO), airway responsiveness, airway obstruction, and serum total immunoglobulin E (IgE). Methods: Within a sampling frame of 21 162 twin subjects, 20-49 years of age, from the Danish Twin Registry, a total of 575 subjects (256 intact pairs and 63 single twins) who either themselves and/or their co-twins reported a history of asthma at a nationwide questionnaire survey, were clinically examined. Traits were measured using standard techniques. Latent factor models were fitted to the observed data using maximum likelihood methods. Results: Additive genetic factors explained 67% of the variation in FeNO, 43% in airway responsiveness, 22% in airway obstruction, and 81% in serum total IgE. In general, traits had genetically and environmentally distinct variance structures. The most substantial genetic similarity was observed between FeNO and serum total IgE, genetic correlation (rho(A)) = 0.37, whereas the strongest environmental resemblance was observed between airway responsiveness and airway obstruction, specific environmental correlation (rho(E)) = -0.46, and between FeNO and airway responsiveness, rho(E) = 0.34. Conclusions: Asthma is a complex disease characterized by a set of etiologically heterogeneous biomarkers, which likely constitute diverse targets of intervention.
Databáze: OpenAIRE
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