Increased Risk for Second Primary Malignancies in Women with Breast Cancer Diagnosed at Young Age: A Population-Based Study in Taiwan
| Autor: | Chun Ming Yeh, Kuan Der Lee, Chunghuang Hubert Chan, Chang Hsien Lu, Chih G. Chen, Shin Cheh Chen, Min Chi Chen, Jen Tsun Lin, Shih Hao Huang, Miao Fen Chen |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Risk Oncology medicine.medical_specialty Epidemiology Population Taiwan Breast Neoplasms Breast cancer Internal medicine Epidemiology of cancer medicine Humans Cumulative incidence Registries education Proportional Hazards Models Gynecology education.field_of_study business.industry Incidence Age Factors Cancer Neoplasms Second Primary Middle Aged medicine.disease Survival Analysis Cancer registry Standardized mortality ratio Female Skin cancer business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 17:2647-2655 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-08-0109 |
| Popis: | Studies conducted in Western countries have reported excess risks for second primary malignancies after breast cancer. However, there is little documentation of ethnic differences in these excess risks. Asian women are characterized by younger age at diagnosis of breast cancer, but very few reports are available on the incidences and risks for second primary cancers in this region. Using population-based data from the Taiwan National Cancer Registry (TNCR) for the period 1979 to 2003, we quantified standardized incidence ratios and cumulative incidence of second cancers among 53,783 women with initial diagnoses of breast cancer. Age-specific incidences showed peaks among women in their 40s, and 1,085 cases (2.02%) developed nonbreast second primary cancers. The risk for second cancers differs significantly according to age at diagnosis of breast cancer. In comparison with women diagnosed when ≥50 years (standardized incidence ratio, 0.96; 95% confidence interval; 0.89-1.04), there were significantly greater risks for bone, corpus uterine, ovarian, thyroid, esophageal, kidney and lung cancers, nonmelanoma skin cancer, and leukemia or lymphoma in women diagnosed when |
| Databáze: | OpenAIRE |
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