Systematic implementation of quality-by-design (QbD) to develop NSAID-loaded nanostructured lipid carriers for ocular application: preformulation screening studies and statistical hybrid-design for optimization of variables

Autor:	Dhaval A. Shah, Rutesh H. Dave, Vishal Rathod
Rok vydání:	2020
Předmět:	genetic structures Computer science Pharmaceutical Science Administration Ophthalmic Ibuprofen 02 engineering and technology 030226 pharmacology & pharmacy Quality by Design 03 medical and health sciences Surface-Active Agents 0302 clinical medicine Drug Delivery Systems Drug Discovery medicine Particle Size Pharmacology Drug Carriers organic chemicals Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Dynasan 114 021001 nanoscience & nanotechnology Lipids Nanostructures Drug Liberation Delayed-Action Preparations Drug Design Drug delivery 0210 nano-technology medicine.drug Biomedical engineering
Zdroj:	Drug development and industrial pharmacy. 46(3)
ISSN:	1520-5762
Popis:	The objective of the present project was to develop and optimize the Ibuprofen (IBU)-loaded nanostructured lipid carrier (IBU-NLCs) for sustained-release ocular drug delivery using a quality-by-design (QbD) approach. The BCS class II drug IBU was selected as the model drug for the preparation of IBU-NLCs by melt-emulsification and ultrasonication technique. Extensive preformulation screening of the components of NLC dispersion (i.e. solid and liquid lipid, surfactants, and osmolality agents) was performed. From the various lipids screened, Dynasan
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a1e74ac9b96164fd594012d0ec7546 https://pubmed.ncbi.nlm.nih.gov/32037896 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.