Leucocyte-depleting arterial line filtration does not reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation
| Autor: | Jan Stygall, Michael J. Harrison, Ian J. Mackie, Michael Kemp, James Hooper, W. B. Pugsley, Stanton Newman, Donald C Whitaker |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Time Factors 030204 cardiovascular system & hematology Sensitivity and Specificity Lymphocyte Depletion law.invention 03 medical and health sciences 0302 clinical medicine Troponin T law Internal medicine medicine Cardiopulmonary bypass Humans Radiology Nuclear Medicine and imaging Prospective Studies Coronary Artery Bypass Advanced and Specialized Nursing Fibrillation Pancreatic Elastase biology business.industry General Medicine Cardiac surgery medicine.anatomical_structure Heart Injuries 030228 respiratory system Neutrophil elastase Cardiology biology.protein Absolute neutrophil count Arterial line medicine.symptom Cardiology and Cardiovascular Medicine business Safety Research Filtration Artery |
| Zdroj: | Perfusion. 21:55-60 |
| ISSN: | 1477-111X 0267-6591 |
| Popis: | Introduction: Leucocyte filtration can reduce inflammation and end-organ damage. The aim of this study was to test the cardioprotective effect of systemic leucocyte filtration during cardiopulmonary bypass (CPB) for coronary revascularization. Methods: Sixty patients scheduled for elective coronary artery bypass grafting were prospectively randomised to receive either a test leucocyte-depleting (LD) filter or a control standard arterial line filter in the CPB circuit. Myocardial injury was determined by serum Troponin T concentration up to 72 h postoperatively. In addition, perioperative neutrophil counts, serum elastase and electrocardiograms (ECGs) were evaluated. Results: There was a peak of Troponin T release at 6 h in both groups. There was no difference between LD or control group Troponin T at any time point. No difference in neutrophil count was found. A greater rise in neutrophil elastase occurred in the LD group during CPB and 10 min post CPB (376 and 496 versus 108 and 228 mcg/L, p Conclusions: LD arterial line filters did not confer any cardioprotective effect as measured by Troponin T in elective coronary revascularization cases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|