Modulation of motor cortical excitability by continuous theta-burst stimulation in adults with autism spectrum disorder
| Autor: | Alexander Rotenberg, Alvaro Pascual-Leone, Fae B. Kayarian, Gabrielle Block, Mary A Ryan, Lindsay M. Oberman, Ali Jannati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Autism Spectrum Disorder medicine.medical_treatment CTBS Audiology Polymorphism Single Nucleotide 050105 experimental psychology Article 03 medical and health sciences Young Adult 0302 clinical medicine Physiology (medical) Neuroplasticity medicine Humans 0501 psychology and cognitive sciences Prospective Studies Evoked potential Theta Rhythm Aged business.industry 05 social sciences Motor Cortex Middle Aged medicine.disease Evoked Potentials Motor Sensory Systems Transcranial magnetic stimulation medicine.anatomical_structure Neurology Autism spectrum disorder Cortical Excitability Female Neurology (clinical) business 030217 neurology & neurosurgery Neurotypical Motor cortex |
| Zdroj: | Clin Neurophysiol |
| Popis: | OBJECTIVE. To test whether change in motor evoked potential (ΔMEP) induced by continuous theta-burst stimulation (cTBS) of motor cortex (M1) distinguishes adults with autism spectrum disorder (ASD) from neurotypicals, and to explore the contribution of two common polymorphisms related to neuroplasticity. METHODS. 44 adult neurotypical (NT) participants (age 21–65, 34 males) and 19 adults with ASD (age 21–58, 17 males) prospectively underwent M1 cTBS. Their data were combined with previously obtained results from 35 NT and 35 ASD adults. RESULTS. ΔMEP at 15 minutes post-cTBS (T15) was a significant predictor of diagnosis (p=0.04) in the present sample (n=63). T15 remained a significant predictor in a larger sample (n=91) and when partially imputed based on T10–T20 from a yet-greater sample (N=133). T15 also remained a significant predictor of diagnosis among brain-derived neurotrophic factor (BDNF) Met+ and apolipoprotein E (APOE) ε4− subjects (p’s0.19). CONCLUSIONS. ΔMEP at T15 post-cTBS is a significant biomarker for adults with ASD, and its utility is modulated by BDNF and APOE polymorphisms. SIGNIFICANCE. M1 cTBS response is a physiologic biomarker for adults with ASD in large samples, and controlling for BDNF and APOE polymorphisms can improve its diagnostic utility. |
| Databáze: | OpenAIRE |
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