International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
| Autor: | Christa E. Müller, Joel Linden, Adriaan P. IJzerman, Kenneth A. Jacobson, Bertil B. Fredholm |
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| Rok vydání: | 2011 |
| Předmět: |
In silico
Allosteric regulation Biology Pharmacology law.invention Animals Genetically Modified law Terminology as Topic Purinergic P1 Receptor Agonists medicine Animals Humans Molecular Targeted Therapy Receptor Adenosine A3 Receptor Agonists Clinical pharmacology Receptors Purinergic P1 International Agencies Adenosine Adenosine receptor IUPHAR Nomenclature Report Purinergic P1 Receptor Antagonists Molecular Medicine Neuroscience medicine.drug |
| Zdroj: | Pharmacological Reviews. 63:1-34 |
| ISSN: | 1521-0081 0031-6997 |
| DOI: | 10.1124/pr.110.003285 |
| Popis: | In the 10 years since our previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations. However, there have been so many other developments that an update is needed. The fact that the structure of one of the adenosine receptors has recently been solved has already led to new ways of in silico screening of ligands. The evidence that adenosine receptors can form homo- and heteromultimers has accumulated, but the functional significance of such complexes remains unclear. The availability of mice with genetic modification of all the adenosine receptors has led to a clarification of the functional roles of adenosine, and to excellent means to study the specificity of drugs. There are also interesting associations between disease and structural variants in one or more of the adenosine receptors. Several new selective agonists and antagonists have become available. They provide improved possibilities for receptor classification. There are also developments hinting at the usefulness of allosteric modulators. Many drugs targeting adenosine receptors are in clinical trials, but the established therapeutic use is still very limited. |
| Databáze: | OpenAIRE |
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