Phenotypic and genetic diversity of the traditional Lister smallpox vaccine

Autor: Daniel Garin, Aude Garcel, Robert Drillien, Julien Perino, Jean-Marc Crance, Anne-Laure Favier
Přispěvatelé: Laboratoire de virologie du Centre de Recherches du Service de Santé des Armées (CRSSA), Ministère de la Défense, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, École du Val de Grâce (EVDG), Service de Santé des Armées, Peney, Maité, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2009
Předmět:
viruses
Sequence Homology
Viral Plaque Assay
Virus Replication
chemistry.chemical_compound
Mice
Cricetinae
Chlorocebus aethiops
Orthopoxvirus
Smallpox vaccine
Lung
Phylogeny
0303 health sciences
education.field_of_study
Mice
Inbred BALB C
biology
Brain
virus diseases
3. Good health
Infectious Diseases
Chordopoxvirinae
Molecular Medicine
Female
Variola virus
Smallpox Vaccine
Population
Vaccinia virus
Cell Line
03 medical and health sciences
medicine
Smallpox
Animals
Humans
Poxviridae
education
030304 developmental biology
General Veterinary
General Immunology and Microbiology
030306 microbiology
Body Weight
Public Health
Environmental and Occupational Health
Genetic Variation
[SDV.ETH] Life Sciences [q-bio]/Ethics
biology.organism_classification
medicine.disease
Virology
Survival Analysis
[SDV.ETH]Life Sciences [q-bio]/Ethics
chemistry
Vaccinia
Zdroj: Vaccine
Vaccine, Elsevier, 2009, 27 (5), pp.708-17. ⟨10.1016/j.vaccine.2008.11.063⟩
Vaccine, 2009, 27 (5), pp.708-17. ⟨10.1016/j.vaccine.2008.11.063⟩
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2008.11.063⟩
Popis: International audience; As an initial step in the development of a second-generation smallpox vaccine derived from the Lister strain, to be prepared for a variola virus threat, diversity of the traditional vaccine was examined by characterizing a series of ten viral clones. In vitro and in vivo phenotypic studies showed that the biological behavior of the clones diverged from each other and in most cases diverged from the vaccinia virus (VACV) Lister parental population. Taken together, these results demonstrate the heterogeneity of the viral population within the smallpox vaccine and highlight the difficulty in choosing one clone which would meet the current requirements for a safe and effective vaccine candidate.
Databáze: OpenAIRE
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