Cumulative probabilities of live birth across multiple complete IVF/ICSI cycles: a call for attention

Autor: Miguel Angel García-Pérez, Raúl Gómez, Juan J. Tarín, Eva C. Pascual, Antonio Cano, Santiago Pérez-Hoyos
Rok vydání: 2019
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
Pregnancy Rate
medicine.medical_treatment
Oocyte Retrieval
Fertilization in Vitro
Gee
Odds
03 medical and health sciences
Young Adult
0302 clinical medicine
Embryo cryopreservation
Pregnancy
Genetics
medicine
Humans
Sperm Injections
Intracytoplasmic
Birth Rate
Assisted Reproduction Technologies
Generalized estimating equation
Genetics (clinical)
Infertility
Male
Retrospective Studies
Gynecology
030219 obstetrics & reproductive medicine
In vitro fertilisation
business.industry
Infant
Newborn
Pregnancy Outcome
Obstetrics and Gynecology
Retrospective cohort study
General Medicine
Embryo Transfer
Embryo transfer
030104 developmental biology
Reproductive Medicine
Female
business
Live birth
Infertility
Female
Live Birth
Developmental Biology
Zdroj: J Assist Reprod Genet
ISSN: 1573-7330
Popis: PURPOSE: To call attention to the fact that cumulative live birth (LB) proportions exhibit an inverted pattern to that displayed by each individual oocyte retrieval cycle (ORC-specific LB proportions) as well as when grouping together all the ORCs undergone by a woman (TNORC-specific LB proportions). METHODS: A retrospective study of 1433 infertile women that had a LB using autologous fresh or frozen embryos and/or dropped out of IVF/ICSI treatment after completing a maximum number of three treatment cycles. Generalized Estimating Equations (GEE) and standard and landmark Kaplan-Meier survival analyses were applied. RESULTS: A standard Kaplan-Meier analysis indicated that cumulative LB proportions rose as number of ORCs increased (0.320, 0.484, and 0.550 at ORC 1, 2, and 3, respectively). In contrast, landmark ORC-specific LB proportions showed an inverted pattern (0.320, 0.242, and 0.127 at ORC 1, 2, and 3, respectively). GEE models revealed that women’s clinical outcomes decreased as TNORCs increased. In particular, compared to women that experienced just one ORC, women that underwent two and three ORCs displayed higher incidences of cycle cancellations before either oocyte retrieval or embryo transfer, and clinical pregnancy losses, and lower odds of LB. CONCLUSION: Infertile women should be informed that cumulative LB probabilities exhibit an inverted pattern to that displayed by each individual ORC as well as when grouping together all the ORCs undergone by a woman.
Databáze: OpenAIRE
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