Higher Level of Dickkopf-1 is Associated with Low Bone Mineral Density and Higher Prevalence of Vertebral Fractures in Patients with Ankylosing Spondylitis

Autor: Ombretta Viapiana, Francesco Ghellere, Maurizio Rossini, Davide Gatti, Elena Fracassi, Maria Rosaria Povino, Vidya Satheesn Kunnathully, Silvano Adami, Luca Idolazzi, S. Troplini
Rok vydání: 2015
Předmět:
musculoskeletal diseases
0301 basic medicine
Adult
Genetic Markers
Male
medicine.medical_specialty
Sclerostin
Endocrinology
Diabetes and Metabolism
Radiography
Osteoporosis
Enzyme-Linked Immunosorbent Assay
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Absorptiometry
Photon
Bone Density
Internal medicine
Bone mineral density
medicine
Prevalence
Humans
Orthopedics and Sports Medicine
In patient
Spondylitis
Ankylosing
Adaptor Proteins
Signal Transducing
030203 arthritis & rheumatology
Bone mineral
Ankylosing spondylitis
DKK1
business.industry
Middle Aged
medicine.disease
Surgery
030104 developmental biology
chemistry
Orthopedic surgery
Bone Morphogenetic Proteins
Intercellular Signaling Peptides and Proteins
Spinal Fractures
Lumbar spine
Female
business
Zdroj: Calcified tissue international. 98(5)
ISSN: 1432-0827
Popis: Patients with ankylosing spondylitis (AS) have an increased risk of bone loss and vertebral fractures. In this study, we explored the hypothesis that the excess bone loss and vertebral fractures might be related with the activity of the Wingless signaling pathway, and in particular with the serum levels of its circulating inhibitors, Sclerostin and Dickkopf-1 (DKK1). We recruited 71 patients diagnosed with AS. Lateral radiographs of the total spine were analyzed to detect the presence of vertebral fractures, and bone mineral density (BMD) was assessed in all patients using dual X-ray absorptiometry at lumbar spine and proximal femoral site. Blood samples were obtained and levels of C-reactive protein (CRP), DKK1, and Sclerostin were measured. Blood samples from 71 healthy sex- and age-matched volunteers were collected to be used as controls. Vertebral fractures were detected more commonly among men than in women (29 vs 8 %, respectively). DKK1, but not Sclerostin serum levels, were inversely correlated to lumbar spine Z-score BMD. Patients with one or more prevalent vertebral fractures had significantly higher DKK1 levels, without significant difference in Sclerostin serum levels. A significant positive correlation was found between DKK1 serum levels and CRP (r = 0.240, p = 0.043). The association we found between serum DKK1 levels and BMD values and vertebral fracture prevalence suggests that DKK1 might contribute to the severity of osteoporosis in AS.
Databáze: OpenAIRE
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