Human papillomavirus and carcinogenesis: novel mechanisms of cell communication involving extracellular vesicles
| Autor: | Giovanna Romeo, Marco Iuliano, Giorgio Mangino, Lorena Capriotti, Maria Vincenza Chiantore, Gianna Fiorucci, Paola Di Bonito |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell signaling Chemokine Carcinogenesis Endocrinology Diabetes and Metabolism Immunology Uterine Cervical Neoplasms α-and β-HPVs Context (language use) Cell Communication Alphapapillomavirus medicine.disease_cause Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Immune system microRNA Gene expression medicine Humans Immunology and Allergy RNA Messenger Skin biology Mechanism (biology) Papillomavirus Infections virus diseases inflammatory cytokines and chemokines mucosal and cutaneous HPVs female genital diseases and pregnancy complications microRNAs 030104 developmental biology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research biology.protein Female extracellular vesicles |
| Zdroj: | Cytokine & Growth Factor Reviews |
| Popis: | Highlights • A group of mucosal HPVs are the causative agents of cervical cancer and are associated to other cancers. • Certain cutaneous HPVs are involved in the development of cutaneous squamous cell carcinoma. • EVs released by HPV+ cells convey a specific cargo of mRNAs and microRNAs. • The EV delivery from HPV+ cells to non-infected recipient cells may represent a novel mechanism of tumorigenesis promotion. A small group of mucosal Human Papillomaviruses are the causative agents of cervical cancer and are also associated with other types of cancers. Certain cutaneous Human Papillomaviruses seem to have a role as co-factors in the UV-induced carcinogenesis of the skin. The main mechanism of the tumorigenesis induced by Human Papillomaviruses is linked to the transforming activity of the viral E6 and E7 oncoproteins. However, other mechanisms, such as the gene expression control by specific microRNAs expression and deregulation of immune inflammatory mediators, may be important in the process of transformation. In this context, the release of Extracellular Vesicles with a specific cargo (microRNAs involved in tumorigenesis, mRNAs of viral oncoproteins, cytokines, chemokines) appears to play a key role. |
| Databáze: | OpenAIRE |
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