| Autor: |
Maria Cristina Leonardi, Andriana Kouloura, Damaris Patricia Rojas, Mattia Zaffaroni, Mattia Intra, Paolo Veronesi, Anna Morra, Marianna Alessandra Gerardi, Cristiana Iuliana Fodor, Maria Alessia Zerella, Anna Maria Camarda, Federica Cattani, Rosa Luraschi, Anna Viola, Giulia Riva, Eleonora Miglietta, Roberto Orecchia, Samantha Dicuonzo, Barbara Alicja Jereczek-Fossa |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Br J Radiol |
| ISSN: |
1748-880X |
| Popis: |
Objectives: The aim of this study is to evaluate feasibility of salvage 4-week hypofractionated whole breast radiotherapy (WBRT) in patients with in-breast recurrence after receiving intraoperative radiotherapy with electrons (IOERT) for primary breast cancer (BC). Methods: BC patients who had repeated quadrantectomy underwent modified WBRT with intensity-modulated radiotherapy using Helical Tomotherapy to underdose the IOERT region. This approach, called POLO (Partially Omitted Lobe), excluded the IOERT volume from receiving the full prescription dose. Results: Nine patients were treated with this approach, receiving 45 Gy in 20 fractions. A simultaneous integrated boost of 2.5 Gy in 20 fractions was delivered in 6/9 patients. Dose constraints and planning objectives were reported. No severe toxicity was reported while local control and overall survival were 100%. Conclusion: The POLO approach is technically feasible and capable to achieve a significant reduction of radiation dose delivered to the previous treated IOERT area. Advances in knowledge: The study demonstrates the technical and dosimetric feasibility of conservative salvage whole breast radiotherapy, while sparing the area already treated with IORT, in patients with in-breast recurrence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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