Angiotensin II and endothelin-1 receptor antagonists have cumulative hypotensive effects in canine Page hypertension
| Autor: | Julian Donckier, PE Massart, Henri Van Mechelen, Guy R. Heyndrickx, André A. Charlier, Jean-Marie Ketelslegers, Dominique Hodeige |
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| Rok vydání: | 1998 |
| Předmět: |
Endothelin Receptor Antagonists
medicine.medical_specialty Angiotensin receptor Physiology Radioimmunoassay Blood Pressure Losartan Renovascular hypertension Angiotensin Receptor Antagonists Dogs Bolus (medicine) Internal medicine Internal Medicine medicine Animals Infusions Intravenous Sulfonamides Endothelin-1 biology business.industry Angiotensin II Bosentan Angiotensin-converting enzyme Receptor Endothelin A medicine.disease Disease Models Animal Hypertension Renovascular Endocrinology Pathophysiology of hypertension biology.protein Vascular Resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Hypertension. 16:835-841 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/00004872-199816060-00015 |
| Popis: | OBJECTIVE: To evaluate whether the cumulative hypotensive effect of the endothelin-1 receptor antagonist bosentan, previously demonstrated in the presence of an angiotensin converting enzyme inhibitor, persists under angiotensin II receptor blockade with losartan. DESIGN: The model of hypertension was canine renovascular hypertension (Page hypertension). METHODS: Ten conscious dogs, studied on two occasions, were administered losartan (a 0.1 mg/kg bolus plus 90 min infusion at 0.1 mg/kg per min) and then bosentan vehicle (experiment I) or losartan and then two cumulative doses of bosentan (a 0.3 mg/kg bolus plus 30 min infusion at 0.7 mg/kg per min; and a 3 mg/kg bolus plus 30 min infusion at 7 mg/kg per min; experiment II). RESULTS: At the end of the study, mean aortic pressure in dogs had decreased by 14% in experiment I (from 139 +/- 4.7 to 119 +/- 4.7 mmHg, P |
| Databáze: | OpenAIRE |
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