Insulin-like growth factor binding protein-3 in preterm infants with retinopathy of prematurity

Autor: Ali Peirovifar, Haleh Mostafidi, Karim Sadeghi, Manizheh Mostafa Gharehbaghi
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
360 retinopexy
lens diameter
ocular trauma
pupil
Growth
Insulin-like growth factor-binding protein
phenylephrine hydrochloride
Pathogenesis
silicone oil tamponade
lcsh:Ophthalmology
disaccommodation
retinopathy of prematurity
lens thickness
lens wet weight
tissue plasminogen activator
biology
Obstetrics
lens dry weight
Gestational age
Retinopathy of prematurity
human adult
Insulin-like growth factor-1
Gestation
Apgar score
Original Article
Female
Infant
Premature

subretinal hemorrhage
medicine.medical_specialty
Accommodation
velocity
Birth weight
vitrectomy
Enzyme-Linked Immunosorbent Assay
Gestational Age
polypoidal choroidal vasculopathy
mydriasis
encirclage
Silicone oil removal
medicine
Humans
submacular hemorrhage
business.industry
Age-related macular degeneration
insulin-like growth factor binding protein-3
oil emulsification
Infant
Newborn

medicine.disease
Infant newborn
eye diseases
retinal macroaneurysm
Ophthalmology
Insulin-Like Growth Factor Binding Protein 3
lcsh:RE1-994
chorodial neovascularization
biology.protein
business
Zdroj: Indian Journal of Ophthalmology, Vol 60, Iss 6, Pp 527-530 (2012)
Indian Journal of Ophthalmology
ISSN: 1998-3689
0301-4738
Popis: Background: Retinopathy of prematurity (ROP) is the main cause of visual impairment in preterm newborn infants. Objective: This study was conducted to determine whether insulin-like growth factor binding protein -3 (IGFBP-3) is associated with proliferative ROP and has a role in pathogenesis of the disease in premature infants. Materials and Methods: A total of 71 preterm infants born at or before 32 weeks of gestation participated in this study. Studied patients consisted of 41 neonates without vaso-proliferative findings of ROP as the control group and 30 preterm infants with evidence of severe ROP in follow up eye examination as the case group. Blood samples obtained from these infants 6-8 weeks after birth and blood levels of IGFBP-3 were measured using enzyme-linked immunosorbent assay (ELISA). Results: The mean gestation age and birth weight of the studied patients were 28.2±1.6 weeks and 1120.7±197 gram in the case group and 28.4±1.6 weeks and 1189.4±454 gram in the control group (P=0.25 and P=0.44 respectively). The infants in the case group had significantly lower Apgar score at first and 5 min after birth. Insulin-like growth factor binding protein -3 (IGFBP-3) was significantly lower in the patients with proliferative ROP than the patients without ROP [592.5±472.9 vs. 995.5±422.2 ng/ml (P=0.009)]. Using a cut-off point 770.45 ng/ml for the plasma IGFBP-3, we obtained a sensitivity of 65.9% and a specificity of 66.7% in the preterm infants with vasoproliferative ROP. Conclusion: Our data demonstrated that the blood levels IGFBP-3 was significantly lower in the patients with ROP and it is suspected that IGFBP-3 deficiency in the premature infants may have a pathogenetic role in proliferative ROP.
Databáze: OpenAIRE