Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats
| Autor: | Zheng-Hong Qin, Xinghong Jiang, Dian-Chen Wu, Shan Gong, Xi-Ping Zhou, Qi Zhu, Paul F. Reid, Qi-Zhang Yin, Bo-Chao Cheng |
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| Rok vydání: | 2008 |
| Předmět: |
Atropine
Male Time Factors medicine.drug_class Narcotic Antagonists viruses Pain (+)-Naloxone Pharmacology Toxicology Serotonergic chemistry.chemical_compound Dorsal raphe nucleus Opioid receptor Muscarinic acetylcholine receptor medicine Animals Rats Wistar Neurotransmitter Neurons Analgesics Dose-Response Relationship Drug Intralaminar Thalamic Nuclei Naloxone Chemistry Antagonist Parasympatholytics Crotoxin Rats medicine.anatomical_structure Anesthesia Neuron |
| Zdroj: | Toxicon. 51:102-111 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2007.08.009 |
| Popis: | Crotoxin (Cro), the principal neurotoxic component of Crotalus durissus terrificus, has been previously reported to have a behavioral analgesic effect in rats and mice. The present study investigated electrophysiologically the effect of Cro on pain-evoked unit discharge of neurons in thalamic parafascicular nucleus (Pf) and underlying mechanisms of its effect. The electrical discharge of Pf neurons was recorded with the microelectrode technique in rats. Intracerebroventricular (i.c.v.) injection of Cro at 0.25, 0.45 and 0.65 microg/kg resulted in a dose-dependent inhibitory effect on the pain-evoked discharge of Pf neurons. The discharge frequency and the discharge duration significantly (P |
| Databáze: | OpenAIRE |
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