Chagas Heart Disease
| Autor: | Antonio Carlos Carvalho, Jamshid Shirani, Randin Nelson, Louis M. Weiss, Louis V. Kirchhoff, Fabiana S. Machado, Christina M. Coyle, David C. Spray, Shankar Mukherjee, Susan P. Montgomery, Fnu Nagajyothi, Michael P. Lisanti, Linda A. Jelicks, Herbert B. Tanowitz, Fangxia Guan, Cibele M. Prado |
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| Rok vydání: | 2012 |
| Předmět: |
Chagas Cardiomyopathy
Chagas disease Pacemaker Artificial medicine.medical_specialty Heart disease Trypanosoma cruzi Disease Article Mice Internal medicine medicine Animals Humans Nifurtimox Life Cycle Stages Endothelin-1 business.industry Dilated cardiomyopathy General Medicine medicine.disease Trypanocidal Agents Defibrillators Implantable Rats Transplantation Disease Models Animal Early Diagnosis Echocardiography Vasoconstriction Benznidazole Heart failure Cardiology Eicosanoids Heart Transplantation Cardiology and Cardiovascular Medicine business Magnetic Resonance Angiography Stem Cell Transplantation medicine.drug |
| Zdroj: | Cardiology in Review. 20:53-65 |
| ISSN: | 1061-5377 |
| Popis: | Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease. |
| Databáze: | OpenAIRE |
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