The effects of various peptides on human isolated gut muscle
| Autor: | I F Stamford, S R Bloom, Gareth J. Sanger, Alan Bennett |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) Colon Muscle Relaxation Vasoactive intestinal peptide Pharmaceutical Science Motility Substance P Biology chemistry.chemical_compound Internal medicine medicine Humans Drug Interactions Galanin Pharmacology Stomach Muscle Smooth Acetylcholine Intestines Endocrinology chemistry Gastrointestinal hormone medicine.symptom Peptides Neurotensin Muscle contraction Muscle Contraction Vasoactive Intestinal Peptide |
| Zdroj: | The Journal of pharmacy and pharmacology. 44(12) |
| ISSN: | 0022-3573 |
| Popis: | The effects of eleven peptides of gastrointestinal origin have been studied on the contraction, relaxation and spontaneous activity of circular and longitudinal muscle strips from different regions of the human gastrointestinal tract. The effects varied with the peptides and sometimes with the region and muscle layer. There was either contraction, no effect, or relaxation and/or inhibition of an acetylcholine-induced contraction. Responses to some peptides are consistent with the possibility that they may contribute directly to the control of motility: galanin, neurotensin and substance P might be involved in contraction, and vasoactive intestinal peptide, peptide histidine isoleucine and peptide histidine methionine might be inhibitory transmitters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text